I’ve been running on Vista for a while now. Unfortunately VS 2005 wasn’t designed with a “least user priveledge” approach in mind and so it has some unsupported scenarios when running on Vista when UAC is turned on. Most stuff “just works”, but there are a few things that require you to kick it into elevated permissions mode. Here’s a FAQ Microsoft just released that provides workarounds those problems and a few others. Looks like we won’t see full Vista support until the Q107 timeframe.